天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (增刊1): 95-98.doi: 10.16333/j.1001-6880.2017.S.020

• 研究简报 • 上一篇    下一篇

大黄酚复合物的稳定性研究

李红1,吴振2*,陈岗2,顾佳玺3,詹永2,谭红军2   

  1. 1 重庆市食品药品检验检测研究院,重庆 401121;2重庆市中药研究院,重庆 400065;3重庆资源与环境交易所,重庆 401147
  • 出版日期:2017-08-02 发布日期:2017-08-02

Stability of Inclusion Complex of Chrysophanol

LI Hong1,WU Zhen2*,CHEN Gang2,GU Jia-xi3,ZHAN Yong2,TAN Hong-jun2   

  1. 1 Chongqing Institute for Food and Drug Control,Chongqing 401121,China;2Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China;3Chongqing Resources and Environment Exchange,Chongqing 401147,China
  • Online:2017-08-02 Published:2017-08-02

摘要: 考察大黄酚酵母葡聚糖复合物(Chr-β-glu)的稳定性,为其剂型选择、工艺设计与贮存条件的确定提供实验依据。对Chr-β-glu进行高温处理、强光照射、不同pH和介质试验,采用动力学方法建立Chr-β-glu降解速率方程,考察其对复合物中大黄酚影响。Chr-β-glu具有一定的热稳定性、抗光照特性,但高pH条件下复合物不稳定;介质种类对其影响较大。Chr-β-glu的稳定性与温度、光照强度、pH值和介质种类关系密切。Chr-β-glu应在低温、避光的条件下贮存,应在低pH值条件下使用。

关键词: 大黄酚, 酵母葡聚糖复合物, 稳定性, 降解动力学

Abstract: To provide the experimental basis for the formulation selection,process design and storage conditions,the stability of inclusion complex of Chr and  βglucan (Chr-β-glu) was investigated.The influences of temperate,light intensity,pH and different solvent on the stability of Chr-β-glu was evaluated by degradation rate equation.It showed that Chr-β-glu had anti-light stability and thermal stability.However,the complex degradation rate was increased at high pH level.Its stability was great influenced by different solvent. The stability of Chr-β-glu is closely related to light intensity,temperate,pH and solvent type.So it should be stored in low temperature,keep out in sun and should be used in low pH level.

Key words: Chrysophanol, yeast glucan complex, stability, degradative kinetics