天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (增刊1): 99-102.doi: 10.16333/j.1001-6880.2017.S.021

• 研究简报 • 上一篇    下一篇

豆腐果苷抗抑郁活性的研究

杨敏*   

  1. 云南农业大学香料研究所,昆明 650201
  • 出版日期:2017-08-02 发布日期:2017-08-02

Antidepressant Activity of Helicid

YANG Min*   

  1. Institute of Flavour and Fragrance,Yunnan Agriculture university,Kunming 650201,China
  • Online:2017-08-02 Published:2017-08-02

摘要: 采用小鼠悬尾实验及小鼠强迫游泳实验方法研究豆腐果苷的抗抑郁作用。在小鼠悬尾实验和小鼠强迫游泳实验中,豆腐果苷在30 mg/kg剂量下能明显缩短小鼠的悬尾不动时间,在20 mg/kg剂量下能明显缩短小鼠强迫游泳的不动时间,豆腐果苷在行为绝望动物模型中呈现抗抑郁作用。

关键词: 豆腐果苷, 抗抑郁, 悬尾, 强迫游泳

Abstract: The antidepressant effect of helicid was evaluated with mice tail suspension test and mice forced swimming test.Helicid 30 mg/kg significantly reduced the accumulative immobility time in mice tail suspension test.Helicid 20 mg/kg reduced the accumulative immobility time in the mice forced swimming test.Helicid has the significant effect of antidepressant in the mice behavioral despair tests.

Key words: helicid, antidepressant, mice tail suspension test, mice forced swimming test