连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究

doi:10.16333/j.1001-6880.2017.9.015

天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (9): 1542-1545.doi: 10.16333/j.1001-6880.2017.9.015

所属专题： No.7

连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究

党珏，袁岸，罗林，全云云，赵梦杰，李芸霞*

成都中医药大学药学院教育部中药材标准化重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地，成都 611137

出版日期:2017-09-27 发布日期:2017-09-27
基金资助:
国家自然科学基金（81373943，81573583）；四川省杰出青年基金（2013JQ0018）；四川省科技厅省青年科技创新研究团队专项计划项目（2017TD0001，2015TD0028，2016TD0006）；成都中医药大学科技发展基金（ZRYB20 1425）

Antipyretic Effect of Forsythia suspense Extract and Forsythia Oil on Yeast-induced Fever Rats and Its Mechanism

DANG Jue, YUAN An, LUO Lin, QUAN Yun-yun, ZHAO Meng-jie, LI Yun-xia*

Pharmacy College, Chengdu University of Traditional Chinese Medicine, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-founded by Chengdu, Chengdu 611137, China

Online:2017-09-27 Published:2017-09-27

摘要/Abstract

摘要： 对比观察连翘提取物和连翘挥发油对酵母菌所致发热大鼠的解热效应和机制。酵母菌皮下注射复制大鼠发热模型。测基础体温后，随机分为空白组、模型组、连翘提取物组（25生药g/kg）和连翘挥发油组（26.7生药g/kg）四组，动态观察给药后大鼠2 h体温和下丘脑cAMP和PGE2含量。结果表明连翘提取物和连翘挥发油均可显著降低酵母致热大鼠的体温（P<0.01或P<0.05），能显著降低下丘脑中cAMP（P<0.05）含量；另外连翘提取物能显著降低下丘脑中PGE-2（P<0.05）含量。连翘提取物有下调下丘脑中cAMP、PGE-2作用，连翘挥发油通过下调下丘脑cAMP发挥解热作用，可用于临床发热的对症治疗。

关键词: 解热, 连翘提取物, 连翘挥发油, 下丘脑cAMP, PGE-2

Abstract: Antipyretic effect and mechanisms of Forsythia suspensa extract and forsythia oil on rats with high fever induced by yeast were investigated in the study. Rat model of yeast-induced fever was established by subcutaneous injections of yeast. After the basal body temperature was measured, the rats were randomly divided into four groups:control group,model group, Forsythia extract group (25 crude drug g/kg) andforsythia oil group (26.7 crude g/kg). Then the body temperature and the concentration of prostaglandin E2 (PGE-2) and cyclic adenosine monophosphate (cAMP) in the hypothalamus cerebrospinal fluid of rats were detected dynamically two hours after dosing. The result showed that F.suspensa extract and forsythia oilcan significantly decrease the temperature(P<0.01 or P <0.05)as well as hypothalamus cAMP content (P<0.01) in yeast-induced fever rats.In addition, F.suspensa extract also obviously decreased hypothalamus PGE-2 content (P<0.01). F.suspensa extract can down-regulate cAMP and PGE-2 in hypothalamus. And forsythia oil down-regulate cAMP in hypothalamus. Both can be used as symptomatic treatment for clinical fever.

Key words: Forsythia suspensa extract, forsythia oil, antipyretic mechanism, cAMP, PGE-2

中图分类号: null

党珏，袁岸，罗林，全云云，赵梦杰，李芸霞*. 连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究[J]. 天然产物研究与开发, 2017, 29(9): 1542-1545.

DANG Jue, YUAN An, LUO Lin, QUAN Yun-yun, ZHAO Meng-jie, LI Yun-xia*. Antipyretic Effect of Forsythia suspense Extract and Forsythia Oil on Yeast-induced Fever Rats and Its Mechanism[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(9): 1542-1545.

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连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究

Antipyretic Effect of Forsythia suspense Extract and Forsythia Oil on Yeast-induced Fever Rats and Its Mechanism

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