天然产物研究与开发 ›› 2018, Vol. 30 ›› Issue (9): 1558-1564.doi: 10.16333/j.1001-6880.2018.9.015

• 研究简报 • 上一篇    下一篇

倒挂金钩中酚类成分的研究

杨龄1,肖春贵2,海青山3,王子明1,王赟1,王扣1*,王飞2*   

  1. 1昆明医科大学药学院暨云南省天然药物药理重点实验室,昆明650500;2云南西力生物技术股份有限公司,昆明 650201;3云南中医学院基础医学院,昆明650500
  • 出版日期:2018-10-08 发布日期:2018-10-10
  • 基金资助:

    云南省科技厅-昆明医科大学应用基础研究联合专项(2014FB014);昆明医科大学“百名中青年学术和技术骨干”培养计划(60117190410);昆明医科大学研究生创新基金(2017S072);昆明医科大学药学院研究生学院基金(YJYTC2017-3)

Phenolic Constituents from Uncaria lancifolia

YANG Ling1,XIAO Chun-gui2,HAI Qing-shan3,JIN Ya-ju3,WANG Zi-ming1,WANG Yun1,WANG Kou1*,WANG Fei2*   

  1. 1School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology,Kunming Medical University,Kunming 650500,China; 2BioBioPha Co.,Ltd,Kunming 650201,China; 3School of Basic Medical Science,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China
  • Online:2018-10-08 Published:2018-10-10

摘要: 综合运用多种色谱技术从倒挂金钩茎枝的95%乙醇提取物中分离得到了19个酚类成分,根据理化性质及波谱学方法鉴定为:表儿茶素(1)、儿茶素(2)、金鸡纳素Ia(3)、金鸡纳素Ib(4)、金鸡纳素Ⅱa(5)、金鸡纳素Ⅱb(6)、原花青素B2(7)、原花青素B5(8)、原花青素C1(9)、hedyotol D(10)、落叶松树脂醇(11)、(+)-松脂素(12)、9-O-(Z)-阿魏酰落叶松脂(13)、9-O-(E)-阿魏酰落叶松脂(14)、(+)-lyoniresinol 9′-O-glucoside(15)、pomegralignan(16)、东莨菪内酯(17)、臭矢菜素B(18)和hymexelsin(19)。所有化合物均首次从该植物中分离得到,其中化合物7~14、16、19首次从钩藤属分离得到。

关键词: 倒挂金钩, 酚类, 原花青素, 木脂素, 香豆素

Abstract: Phytochemical investigation on the 95% ethanol extract of Uncaria lancifolia led to the isolation of 19 phenolic compounds,including epicatechin (1),catechin (2),cinchonain Ia (3),cinchonain Ib (4),cinchonain Ⅱa (5),cinchonain Ⅱb (6),procyanidin B2 (7),procyanidin B5 (8),procyanidin C1 (9),hedyotol D (10),(±)-lariciresinol (11),(+)-pinoresinol (12),9-O-(Z)-feruloyllariciresinol (13),9-O-(E)-feruloyllariciresinol (14),(+)-lyoniresinol 9′-O-glucoside (15),pomegralignan (16),scopoletin (17),cleomiscosin B (18) and hymexelsin (19).This is the first reporting for the chemical constituents of U.lancifolia.All compounds were obtained from this plant for the first time.Among them,ten compounds including 7-14,16 and 19 were isolated from Uncaria genus for the first time.

Key words: Uncaria lancifolia, phenolic compounds, proanthocyanidins, lignans, coumarins

中图分类号: 

R284.2 Q946.9