关键词: (2E, 4E)-N-（2-氨基乙基-5-（苯并［d］［1, 3］［二氧杂环戊烯］-5基）戊-2, 4-二烯酰胺, 合成, 高脂血症大鼠模型, 降血脂

Abstract: Using sodium metal as a catalyst to synthesize (2E,4E)-N-(2-amino ethyl-5-(benzo［d］［1,3］ ［dioxol］-5-yl)penta-2,4-dien acid amide (C₁₄H₁₆ N₂O₃,ethylenediamine pepper acid,EPA) by heating reflux，the structure was characterized and identified with XRD,IR,¹H,¹³C NMR.The yield of the EPA was served as the indicator to research the optimization of the synthetic technological condition.The results of the experiments indicated that the amount of catalyst was 1.0 g (N₂ protection),the temperature of heating reflux was 65-70 ℃,and the reaction time was 45-48 h,which were the preferable synthetic technological condition,and the synthetic yield of )EPA could reach over 62.93%.These results can provide the design basis for industrial production.In addition,aiming at the rats with hyperlipidemia,EPA Pepper acid hexamethylenediamine can dose-dependently reduce the serum LDL-C,TG and TC level.Besides,it can significantly elevate the HDL-C level,serum SOD and GSH-PX activities,and reduce the amount of MDA.Compared with simvastatin，EPA pepper acid hexamethylenediamine can mainly reduce LDL-C．Another,EPA also has some lipid-lowering and anti-oxidation efficients.

Key words: (2E,4E)-N-(2-amino ethyl-5-(benzo［d］［1,3］［dioxol］-5-yl)penta-2,4-dien acid amide, synthesis, hyperlipemia model rats, lower blood lipid