关键词: 核桃青皮, 胡桃科, 化学成分, 抗肿瘤活性

Abstract: The experiment aimed to investigate the chemical compositions of Walnut green husk and the antitumor activities of the isolated compounds.The chemical constituents were isolated and purified by column chromatography and recrystallization,and their structures have been elucidated on the basis of spectral data analysis.As a result,thirteen compounds were isolated and identified as 3,5-dimethoxy-4-hydroxy benzene carbonic-7-O-β-D-pyranglucose (1),myricanain F (2),β-stitosterol (3),oleanolic acid (4),regiolone (5),asiatic acid (6),hederagenin (7),β-daucosterin (8),(R)-8-hydroxy-α-tetralone-O-β-D-glucopyranoside (9),3β,23-dihydroxy-urs-12-en-28-oic acid (10),ursolic acid (11),syringc acid (12),Juglanoside B (13).Compounds 1,2,6,7,9 and 10 are all separated from the genus for the first time.Furthermore,compound 4 showed strong inhibitory activity towards human carcinoma (HepG-2),and compound 9 showed moderate inhibitory activity towards human breast cancer cells (MCF-7).

Key words: Walnut green husk, juglandaceae, chemical constituents, antitumor activity