关键词: 小青龙汤, 哮喘, 网络药理学, 生物信息学, 分子对接

Abstract: To elucidate the mechanism of Xiaoqinglong decoction in the treatment of asthma from the molecular level and explore the potential target of Xiaoqinglong decoction.This study searched the Chinese medicine system pharmacology database and analysis platform (TCMSP) and screened the active ingredients of Xiaoqinglong decoction according to oral bioavailability (OB) and drug-likeness (DL),Pharmmapper database was screened as well.The potential target of Xiaoqinglong decoction,mining CTD,Genecards database to screen the target related to asthma,using Cytoscape 3.6.1 software to construct the protein interaction network map of Xiaoqinglong decoction,compound target map and find small by calculating topological parameters Key targets and compounds in Xiaoqinglong decoction.GO analysis and KEGG analysis were performed on the target of Xiaoqinglong decoction on asthma.The iGEMDOCK software was used to predict the binding of the target to the main compound by molecular docking.The active components and potential targets of Xiaoqinglong decoction were obtained by screening;43 biological processes,11 cell components and 9 molecular functions were obtained by GO analysis;KEGG analysis included PI3K-Akt signaling pathway,HIF-1 signaling pathway,Wnt signal Pathway and other pathways.The mechanism of Xiaoqinglong decoction on the treatment of asthma was preliminarily verified and predicted.Additionally,a reference for further studies was provided.

Key words: Xiaoqinglong decoction, asthma, network pharmacology, bioinformatics, molecular docking