天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (增刊1): 166-171.doi: 10.16333/j.1001-6880.2019.S.027

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鸡骨常山属植物中生物碱研究进展

张金苹1,2,4,王晓静1,2,4*,王志伟3*   

  1. 1济南大学 山东省医学科学院医学与生命科学学院,济南 250200;2山东省医学科学院药物研究所,济南250062;3山东省分析测试中心 齐鲁工业大学(山东省科学院),济南 250014;4国家卫生部生物技术药物重点实验室 山东省罕少见病重点实验室,济南 250062
  • 出版日期:2019-08-06 发布日期:2019-08-06
  • 基金资助:

    国家自然科学基金(31700290);中国科学院沈阳分院-山东省科学院青年科学家合作伙伴项目;山东省医学科学院医药卫生科技创新工程

Research progress on alkaloids of genus Alstonia

ZHANG Jin-ping1,2,4,WANG Xiao-jing1,2,4*,WANG Zhi-wei3*   

  1. 1School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200; 2Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062; 3Shandong Analysis and Test Center,Qilu University of Technology (Shandong Academy of Sciences),Jinan 250014; 4Key Laboratory for Biotech-Drugs Ministry of Health,Key Laboratory for Rare-Uncommon Diseases of Shandong Province,Jinan 250062
  • Online:2019-08-06 Published:2019-08-06

摘要: 鸡骨常山属植物多为云南少数民族地区民间常用药材,含有大量结构复杂,生物活性良好的生物碱类成分,是近年来天然药物化学研究领域的热点。本文主要针对近五年来鸡骨常山属植物中已分离鉴定的76个生物碱类成分及该属植物中化学成分的生物活性进行了系统总结,为更加合理地开发利用鸡骨常山属植物资源提供参考依据。

关键词: 鸡骨常山属, 糖胶树, 鸡骨常山, 生物碱, 研究进展

Abstract: The Alstonia was a common medicinal material in Yunnan minority areas.It contained a large number of alkaloids with complex structure and good biological activity.It was a hot spot in the field of natural medicinal chemistry research in recent years.This paper mainly focused on the 76 alkaloids that have been isolated and identified in the Alstonia in the past five years,and the biological activities of the chemical constituented in this genus,which provided a systematic summary for the more rational development and utilization of Alstonia plants.

Key words: Alstonia, Alstonia scholaris;alkaloids;research progress

中图分类号: 

R931.71