关键词: 幽门螺杆菌相关性胃炎, 半夏, 黄芩, 黄连, 网络药理学

Abstract:

Consulting the previous research,the paper analyzed the main effective compounds and mechanisms of Pinellia, Scutellaria and Coptis in treating Helicobacter pylori associated gastritis based on network pharmacology.The compounds of Pinellia,Scutellaria and Coptis were obtained in the TCMSP platform.The targets of compounds were obtained in the Swiss Target Prediction database.The targets of Helicobacter pylori associated gastritis were obtained in the Gene Cards database and the OMIM database.Constructed a "herbs-compounds-targets" network association diagram and protein-protein interaction to analyze the main effective compounds and targets in Pinellia,Scutellaria and Coptis.A functional enrichment analysis and metabolic pathway of the targets of Pinellia,Scutellaria and Coptis were analyzed in David database.A total of 35 potential active compounds were screened,37 targets were related to disease and 77 pathways were involved.The herapeutic mechanism of Pinellia,Scutellaria and Coptis on the Helicobacter pylori  associated gastritis and regulating the gastric cancer reflects the characteristics of multi-component,multi-target,and multi-pathway,which provides a scientific basis for further explaining the action mechanism and the material basis of Pinellia,Scutellaria and Coptis against Helicobacter pylori associated gastritis.

Key words: Helicobacter pylori associated gastritis, Pinellia, Scutellaria, Coptis, network pharmacology