To explore the mechanism of Fructus Aurantii Immaturus and Radix Paeoniae Alba in the treatment of liver cancer.Using network pharmacology,the active components and related target proteins of Fructus Aurantii Immaturus and Radix Paeoniae Alba were screened from the pharmacology analysis platform of traditional Chinese medicine system;the target of liver cancer was retrieved from GeneCards and OMIM databases,and the biological functions and metabolic pathways of key nodes were analyzed by using the network pharmacology analysis platform and related databases to build the interaction between ztraditional Chinese medicine and disease target proteins Finally,the expression of key proteins in the human protein atlas was found in cancer and normal tissues,and survival analysis was carried out.The results showed that there were 35 active components and 65 common targets in Fructus Aurantii Immaturus and Radix Paeoniae Alba.The results of go analysis involved nuclear receptor function,extracellular space,negative regulation of apoptosis process,chromatin binding,positive regulation and negative regulation of RNA polymerase Ⅱ promoter transcription.KEGG results showed that it was related to hepatitis B,PI3-AKT,TNF and other signal pathways.Sixty-five core genes were screened by PPI network,IL6,VEGFA and EGFR were the top three in the correlation degree,and their high and low expression was correlated with the five-year survival rate of patients with liver cancer.In conclusion,paeoniflorin,neohesperidin and chuanhesperidin,the active components in Fructus Aurantii Immaturus,play the role of positive transcription regulation,nuclear function receptor and apoptosis pathway on IL6,VEGFA,EGFR and other related targets through cancer pathway,PI3-AKT,TNF and other signal pathways,providing a theoretical basis for further empirical research.