天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (1): 150-164.doi: 10.16333/j.1001-6880.2021.1.018

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白僵菌天然产物及其药理活性和生物合成研究进展

谢丽媛1，尹文兵2，李伟2,3*，高伟1*   

  1. 1首都医科大学 中医药学院，北京 100069；2中国科学院微生物研究所，真菌学国家重点实验室，北京 100101；3河南省科学院生物研究所有限责任公司，郑州 450008
  • 出版日期:2021-01-28 发布日期:2021-01-28
  • 基金资助:
    北京高等学校高水平人才交叉培养“实培计划”毕业设计（科研类）协同项目；河南省科学院省级特聘研究员项目（200505006）

Advance on natural products and their pharmacological activities and biosynthesis from Beauveria species

XIE Li-yuan1,YIN Wen-Bing2,LI Wei 2,3*,GAO Wei1*   

  1. 1Capital Medical University,School of Chinese Medicine,Beijing 100069,China; 2Institute of Microbiology Chinese Academy of Sciences,State Key Laboratory of Mycology,Beijing 100101,China;3Henan Academy of Science Institute of Biology Co.,Ltd.,Zhengzhou 450008,China
  • Online:2021-01-28 Published:2021-01-28

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摘要： 白僵菌是重要的昆虫病原真菌，能产生多肽类、聚酮类、生物碱类、苯丙素类、萜类、核苷类等多种结构类型的天然产物，其中很多天然产物显示出优良的抗肿瘤、抗菌、抗病毒和杀虫等活性，具有极大的应用开发潜力。随着白僵菌基因组测序的完成，白僵菌素、白僵菌交酯、球孢交酯、卵孢素及纤细素等活性分子的生物合成基因簇及其生物合成机制已得到阐明，这些研究将大大促进白僵菌来源的新结构活性天然产物的基因组挖掘和发现以及已知重要活性分子的开发应用。本文对已知白僵菌产生的天然产物、药理活性及重要活性分子的生物合成途径进行了概括总结，为系统开发白僵菌天然产物资源提供参考。


关键词: 白僵菌, 天然产物, 生物活性, 基因簇, 生物合成

Abstract:

Beauveria species are important entomopathogenic fungi producing a large variety of natural products including peptides,polyketides,alkaloids,phenylpropanoids,terpenes and nucleosides.These compounds show various bioactivities such as anti-tumor,insecticidal activity,antibacterial action and antiviral activity.Moreover,the biosynthesis pathways of some active molecules including beauvericin,beauveriolide,bassianolide,oosporein and tenellin have been explored based on the development of genome sequencing technology and genetic manipulation.All of which provide a good foundation for discovery of unknown structures by genome mining and application of known active molecules in Beauveria species.In this review,the chemical constituents,bioactivities and the biosynthesis pathways of natural products produced in Beauveria spp. were summarized,and all of which provided the reasons for exploiting systematacially the natural product resourses in Beauveria species.

Key words: Beauveria, natural products, bioactivity, gene cluster, biosynthesis

中图分类号:  R284 R285

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