天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (8): 1430-1438.doi: 10.16333/j.1001-6880.2022.8.017

• 综述 • 上一篇    下一篇

蟾酥抗肿瘤临床应用及其疗效机制的研究进展

刘   娟1，童明慧1，郭英球2，李   娟1,3*   

  1. 1湖南中医药大学；2长沙欧邦生物科技有限公司；3湖南省中药活性物质筛选工程技术研究中心,长沙 410208
  • 出版日期:2022-08-28 发布日期:2022-09-08
  • 基金资助:
    长沙市科技计划（kh1902260）；湖南省卫生健康委科研课题（202213055724），国家级大学生创新创业训练计划（202110541017）；湖南中医药大学中药学一流学科项目（校行科字［2018］3号）

Research progress on clinical application and therapeutic mechanism of Bufonis Venenum for anti-tumor

LIU Juan1,TONG Ming-hui1,GUO Ying-qiu2,LI Juan1,3*   

  1. 1Hunan University of Chinese Medicine;2Changsha Oubang Biotechnology Co.,Ltd.; 3Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM,Changsha 410208,China
  • Online:2022-08-28 Published:2022-09-08

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摘要：

蟾酥是我国传统名贵药材，至今已有悠久的用药历史，随着对蟾酥的深入研究，发现其在抗肿瘤方面具有独特的用药优势。近年来，诸多报道表明蟾酥及其制剂在临床治疗肿瘤中有良好的疗效，不仅有效抑制肿瘤的发展，而且有效改善患者机体免疫力。同时，大量的体内外实验亦证实蟾酥及其成分有确切的抗肿瘤作用。本文综述了近五年蟾酥及其制剂抑制肿瘤细胞增殖、迁移和侵袭，诱导肿瘤细胞凋亡和自噬，逆转肿瘤多药耐药等作用机制以及相关临床应用，为蟾酥抗肿瘤作用机制的深入研究和临床合理用药提供指导依据。

关键词: 蟾酥, 抗肿瘤, 作用机制, 临床应用, 毒性

Abstract:

Bufonis Venenum,as a precious traditional Chinese medicinal material,has a long medicinal history.With the continuous research,its unique drug advantages in anti-tumor have been found.Recently,numerous reports indicate that Bufonis Venenum and its preparations show good curative effect in the clinical treatment of tumors.It not only inhibits growth of tumors but also effectively improve the immunity of body.Meanwhile,Bufonis Venenum and its constituents have been considered very powerful in anti-tumors by a large number of in vivo and in vitro experimentations.This paper reviewed about the anti-tumor clinical application and mechanisms including inhibiting the proliferation,migration,invasion,inducing apoptosis,autophagy of tumor cells,as well as reversing multi-drug resistance of Bufonis Venenum and its preparations in the latest five years,so as to provide guidance for the further study of the anti-tumor mechanisms and clinical rational use of Bufonis Venenum.

Key words: Bufonis Venenum, anti-tumor, mechanisms, clinical application, toxicity

中图分类号:  R285.6

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