天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (10): 1820-1831.doi: 10.16333/j.1001-6880.2023.10.018

• 综述 • 上一篇    

中药治疗腹泻型肠易激综合征的生物靶标研究进展

吴心悦，丁可欣，吴   飞*，林   晓   

  1. 上海中医药大学中药现代制剂技术教育部工程研究中心，上海 201203
  • 出版日期:2023-10-28 发布日期:2023-10-31
  • 基金资助:
    上海市卫生健康委员会科研基金（201940296）

Research progress on biological targets of traditional Chinese medicine in the treatment of diarrhea-type irritable bowel syndrome

WU Xin-yue,DING Ke-xin,WU Fei*,LIN Xiao   

  1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
  • Online:2023-10-28 Published:2023-10-31

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摘要：

腹泻型肠易激综合征（diarrhea-predominant irritable bowel syndrome，IBS-D）是肠易激综合征（irritable bowel syndrome，IBS）最常见的亚型。IBS-D的主要病因包括胃肠道炎症反应、内脏敏感性增加、脑-肠轴异常、肠道微生态紊乱、肠道屏障受损等。在这些病理进程中存在引发IBS-D的关键因子，因此可以寻找IBS-D发病的关键信号通路及关键信号因子，作为治疗IBS-D的生物靶标，通过抑制或调节这些生物靶标，以达到防治IBS-D的目的。研究显示，以中医药途径干预治疗IBS-D是一种安全且有效的方法，无论是单味中药或是中药复方，均显示对IBS-D的发病机制中的多种关键通路及关键信号因子具有调节作用。本文就中药对治疗IBS-D发病进程中的关键生物靶标的研究进展进行综述，为IBS-D治疗药物作用机制探索及新药开发提供思路。

关键词: 中药, 腹泻型肠易激综合征, 生物靶标, 胃肠道炎症, 内脏敏感性

Abstract:

Diarrhea-predominant irritable bowel syndrome (IBS-D) is the most common subtype of irritable bowel syndrome (IBS).The main causes of IBS-D include gastrointestinal inflammation,increased visceral sensitivity,abnormal brain-gut axis,intestinal microecological disorder,and intestinal barrier damage.There are key factors that trigger IBS-D in these pathological processes.Therefore,the key signaling pathways and key signaling factors of the pathogenesis of IBS-D can be sought as biological targets for the treatment of IBS-D,and the purpose of preventing and treating IBS-D can be achieved by inhibiting or regulating these biological targets.Studies have shown that traditional Chinese medicine (TCM) is a safe and effective way to intervene in the treatment of IBS-D.Both single TCM and TCM compound have been shown to have regulatory effects on multiple key pathways and key signaling factors in the pathogenesis of IBS-D.This article reviews the research progress of biological targets related to traditional Chinese medicine in the treatment of the pathogenesis of IBS-D,so as to provide ideas for the exploration of the mechanism of action of drugs for IBS-D and the development of new drugs.

Key words: traditional Chinese medicine, diarrhea-predominant irritable bowel syndrome, biological targets, inflammation of gastrointestinal tract, visceral sensitivity

中图分类号:  R285.5

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