天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (8): 1432-1444.doi: 10.16333/j.1001-6880.2024.8.017

• 综述 • 上一篇    下一篇

牛膝化学成分和药理作用研究进展及其质量标志物（Q-Marker）预测分析

韩永光1，谭雅兰1，张超云2，卞   华2*   

  1. 1河南中医药大学药学院，郑州 450046；2南阳理工学院 河南张仲景方药与免疫调节重点实验室，南阳 473004
  • 出版日期:2024-08-28 发布日期:2024-08-29
  • 基金资助:
    河南省高等学校青年骨干教师培养计划项目(2020GGJS111)；河南省大学生创新创业计划（S202110471030）；河南张仲景方药与免疫调节重点实验室开放课题（KFKT202002）；河南中医药大学2021年度研究生科研创新能力提升计划（2021KY CX053）

Research progress on chemical components and pharmacological effects of Achyranthes bidentata and prediction and analysis of its quality markers

HAN Yong-guang1,TAN Yan-lan1,ZHANG Chao-yun2,BIAN Hua2*   

  1. 1Colleges of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;2 Henan Key Laboratory of Zhang Zhong-jing Formulae and Herbs for Immunoregulation,Nanyang Institute of Technology,Nanyang 473004,China
  • Online:2024-08-28 Published:2024-08-29

PDF (PC)

5

摘要：

牛膝在《神农本草经》中被列为上品，近几年研究证实牛膝的化学成分主要包括甾体、三萜皂苷、多糖、挥发油等化合物，具有抗炎镇痛、调节免疫、抗骨质疏松、保护心血管等药效。本文从牛膝的植物亲缘性，牛膝特有性、有效性、可测性化学成分和炮制后化学成分等方面，对牛膝的质量标志物（quality marker，Q-Marker）进行预测分析，牛膝甾酮A、25S-牛膝甾酮、25R-牛膝甾酮、齐墩果酸-3-O-β-D-(6′-丁酯)-吡喃葡萄糖醛酸苷、齐墩果酸-3-O-β-D-(6′-甲酯)-吡喃葡萄糖醛酸苷、β-蜕皮甾酮等可作为牛膝质量标志物，为建立牛膝质量评价体系和深入研究其药理作用提供依据。

关键词: 牛膝, 化学成分, 药理作用, 质量标志物

Abstract:

Achyranthes bidentata is listed as the top grade in the Shennong Herbal Classic.In recent years,domestic and foreign studies have confirmed there are many types chemical in A. bidentata,including steroids,triterpenoid saponins,polysaccharides and essential oil,which have anti-inflammatory and analgesic effects,immune regulation,anti osteoporosis and cardiovascular protection.Based on the plant′s phylogenetic relationship,the effectiveness of its chemical components,the detectability of its chemical composition and changes of chemical components after processing are made on the potential quality markers (Q-Marker) of A. bidentata.It was preliminarily predicted that achyranterone A, 25R-inokosterone,25S-inokosterone,oleanolic acid-3-O-β-D-(6′-butyl ester)-glucuronopyranoside,oleanolic acid-3-O-β-D-(6′-methyl ester)-glucuronopyranoside and hydroxyecdysone etc.can be potential quality markers of A. bidentata.This review aims to provide the scientific evidence for establishing the quality control and further studying its pharmacological effects of A. bidentata.

Key words: Achyranthes bidentata, chemical composition, pharmacological effect, quality markers

中图分类号:  R961.1

版权所有 © 《天然产物研究与开发》编辑部
地址：四川天府新区群贤南街289号　邮编：610299
电话：028-85210304　QQ群：342035423　Email：trcw@clas.ac.cn; re_trcw@clas.ac.cn　
本系统由北京玛格泰克科技发展有限公司设计开发
总访问量：　今日访问：　在线人数：