天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (8): 1445-1455.doi: 10.16333/j.1001-6880.2024.8.018

• 综述 • 上一篇    

松果菊苷药理作用及机制的研究进展

孙   悦1,包旭宏2,3*,刘文伟2,张国霞2   

  1. 1甘肃中医药大学;2甘肃省中药现代制药工程研究院;3甘肃奇正藏药有限公司,兰州 730000
  • 出版日期:2024-08-28 发布日期:2024-08-29
  • 基金资助:
    国家重点研发计划(2022YFC3502203)

Research progress on the pharmacological action and mechanism of echinacoside

SUN Yue1,BAO Xu-hong2,3*,LIU Wen-wei2,ZHANG Guo-xia2   

  1. 1Gansu University of Traditional Chinese Medicine;2Gansu Institute of Modern Pharmaceutical Engineering of Traditional Chinese Medicine;3Gansu Qizheng Tibetan Medicine Co.,Ltd.,Lanzhou 730000,China
  • Online:2024-08-28 Published:2024-08-29

摘要: 松果菊苷(echinacoside,ECH)为苯乙醇苷类化合物,存在于多种植物中,为极具潜力的中药成分,应用前景广阔。现代药理研究表明ECH具有许多的生物学效应,如神经保护作用、心肌保护作用、肝脏保护作用、抗肿瘤、抗氧化抗衰老,同时还有免疫调节、降糖降脂、促进生殖和骨形成、保护肺血管以及预防动脉粥样硬化等药理作用,可用于多个系统疾病的治疗,对其进行药效机制的进一步探究和开发具有重要意义。因此,该文就近几年来对ECH的药理作用及作用机制研究进行了归纳总结,并对其研究现状及未来方向提出了建议,以期为其进一步深入研究及开发利用提供一定的参考价值。

Abstract:

Echinacoside(ECH) is a phenylethanol glycoside compound that exists in a variety of plants and is a promising traditional Chinese medicine ingredient with broad application prospects.Modern pharmacological studies have shown that ECH has many biological effects,such as neuroprotective,myocardial protective,liver protective,anti-tumor,antioxidant anti-aging,as well as immunomodulation,hypoglycemic and lipid reduction,promotion of reproduction and bone formation,protection of pulmonary blood vessels and prevention of atherosclerosis and other pharmacological effects,which can be used for the treatment of multiple system diseases,and the further exploration and development of its pharmacodynamic mechanism is of great significance.Therefore,this paper summarizes the pharmacological effects and mechanism of ECH in recent years,and puts forward suggestions on its research status and future direction,in order to provide some reference for its further in-depth research,development and utilization.

Key words: echinacoside;pharmacological action, mechanism of action

中图分类号:  R284