桑白皮化学成分的研究

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (3): 399-400.

桑白皮化学成分的研究

郑兆广^1,2*，王汝上¹，汤丹¹，何宝¹，顾斐¹，段婷婷¹，朱荃^1,2*

¹广州康臣药业有限公司肾病药物研究中心，广州510530; ²澳门科技大学中医药学院，澳门 999078

收稿日期:2009-11-27 出版日期:2011-06-25 发布日期:2011-08-08
通讯作者: dzhg168@126.com

Chemical Constituents of Cortex Mori

ZHENG Zhao-guang1,2*, WANG Ru-shang1, TANG Dan1, HE Bao1, GU Fei1, DUAN Ting-ting1, ZHU Quan1,2*

¹The R&D center of drug for renal diseases, Consun pharmaceutical co., LTD, Guangzhou 510530, China; ²School of Traditional Chinese Medicine, Macau University of Science and Technology, Macau 999078, China

Received:2009-11-27 Online:2011-06-25 Published:2011-08-08

摘要/Abstract

摘要：

从桑白皮（Cortex Mori）的水提液中分离得到5个化学成分，通过波谱数据结合理化性质分别鉴定为4,4'-二苯甲烷二氨基甲酸甲酯（4,4'-diphenylmethane-bis(methyl) carbamates, 1），东莨菪内酯（seopoletin，2），伞形花内酯（umbelliferone, 3），3,4,5-三甲氧基苯酚（3,4,5-trimethoxyphenol, 4），对羟基苯甲酸乙酯（4-hydroxy ethylbenzoate, 5）。其中，化合物1为新的天然化合物，4和5为首次从该植物中分得。

关键词: 桑白皮, 二苯甲烷二氨基甲酸甲酯, 东莨菪内酯, 伞形花内酯, 3,4,5-三甲氧基苯酚, 对羟基苯甲酸乙酯

Abstract:

Five compounds were isolated from the water extract of Cortex Mori, on the basis of spectroscopic analysis and physico-chemical property, they were identified as 4,4'-diphenylmethane-bis(methyl) carbamates (1), scopoletin (2), umbelliferone (3), 3,4,5-trimethoxyphenol (4), and 4-hydroxy ethylbenzoate (5). Compound 1 was a new natural compound and compounds 4 and 5 were isolated from this plant for the first time.

Key words: Cortex Mori, 4,4'-diphenylmethane-bis(methyl) carbamates, scopoletin, umbelliferone, 3,4,5-trimethoxyphenol, 4-hydroxy ethylbenzoate

中图分类号:

R284.1

郑兆广，王汝上，汤丹，何宝，顾斐，段婷婷，朱荃. 桑白皮化学成分的研究[J]. 天然产物研究与开发, 2011, 23(3): 399-400.

ZHENG Zhao-guang, WANG Ru-shang, TANG Dan, HE Bao, GU Fei, DUAN Ting-tin, ZHU Qu. Chemical Constituents of Cortex Mori[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(3): 399-400.

参考文献 8

1	Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia,Vol. I (中国药典).Beijing:People’s Medical Publishing House, 2005.209.
2	Wu ZP(吴志平),Tan JZ(谈建中),Gu ZL(顾振纶).Study on chemical constituents and pharmacological activities of Cortex Mori.Chin Wild Plant Res,2004,23(5):10-16.
3	Furer VL.The IR spectra and hydrogen bonding of toluene-2,6-bis(methyl) and4,4'-diphenylmethane-bis(methyl) carbamates.J Mol Structure,2000,520:117-123.
4	Vauthey I,Valot F,Gozzi C,et al.An environmentally benign access to carbamates and ureas.Tetrahedron Lett,2000,41:6347-6350.
5	Qi SH(漆淑华),Wu DG(吴大刚),Luo XD(罗晓东).Coumarins and ellagic acids from Sapium chihsinianum S. 1ee.Nat Prod Res Dev(天然产物研究与开发),2004,16:297-299.
6	Shi Y(施瑶),Li DX(李定祥),Min ZD(闵知大).Chemical constituents of Zanthoxylum dimorphophylum.Chin Tradit Herb Drugs(中草药),2006,37(1):13-15.
7	Ren HY(任宏燕),Cai XY(柴兴云),Lu YN(陆亚男),et al.Studies on the chemical constituents of Flacoutia ramontchii L..China J Chin Mater Med (中国中药杂志),2007,32:862-863.
8	Zhang W(张薇),Zhang WD(张卫东),Li TZ(李廷钊),et al.Studies on the chemical constituents in roots of Daphne odora var. atrocaulis.China J Chin Mater Med (中国中药杂志),2005,30:513-515.

[1]	张欢, 丁纪茹, 张效科. 基于网络药理学和分子对接探索桑白皮治疗糖尿病周围神经病变的潜在机制[J]. 天然产物研究与开发, 2022, 34(1): 121-132.
[2]	吴永祥1，吴丽萍1，胡长玉1，万志兵1，李丰伯1，金泰完2*. 桑白皮中sanggenon B对脂多糖诱导RAW264.7细胞炎症反应的影响[J]. 天然产物研究与开发, 2018, 30(7): 1132-1137.
[3]	曹静亚1,2，谭亮1,2，迟晓峰1,2，胡风祖1,2*. 柴达木栽培和野生枸杞子中东莨菪内酯含量的测定[J]. 天然产物研究与开发, 2014, 26(12): 2004-2007.
[4]	夏郭平，冯煦，陈雨，王鸣，董云发. 北美盐角草(Salicornia bigelovii Torr.)化学成分的研究[J]. 天然产物研究与开发, 2010, 23(6): 1012-1014.