马缨丹根：化学成分及抑制HIV逆转录酶活性

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (1): 25-29.

马缨丹根：化学成分及抑制HIV逆转录酶活性

何俊杰，郑炼付，霍天武，王婷婷，曾和平^*

华南理工大学化学与化工学院，广州 510640

收稿日期:2010-01-11 发布日期:2011-07-20
通讯作者: zenghp@scnu.edu.cn
基金资助:
华南理工大学国家大学生创新性实验计划(项目编号：B15Y9080010)的资助，同时获得国家自然科学基金（20671036），广东省科技计划项目。

Roots of Lantana camara: Chemical Constituents and HIV-1 Reverse Transcriptase Inhibitory Activity

HE Jun-jie, ZHENG Lian-fu, HUO Tian-wu, WANG Ting-ting, ZENG He-ping^*

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Received:2010-01-11 Published:2011-07-20

摘要/Abstract

摘要：

用硅胶柱层析分离马缨丹（Lantana camara L.）根部乙醇浸提物获得25个组分，其中三个组分对HIV逆转录酶（HIV reverse transcriptase，HIV RT）活性有抑制作用。使用减压柱层析从部分组分中分离获得了6个五环三萜类化合物，它们的结构经波谱分析分别鉴定为齐墩果酮酸（oleanonic acid，1）、路路通内酯（liquidambaric lactone，2），马缨丹烯A（lantadene A，3）、马缨丹烯B（lantadene B，4）、齐墩果酸（oleanolic acid，5）和25-羟基-齐墩果酸（25-hydroxy-oleanolic acid，6）。其中，化合物2和6首次从马鞭草科植物中分离得到，同时，首次报道了化合物6的单晶结构。

关键词: 马缨丹根, HIV逆转录酶, 五环三萜类化合物, 单晶结构

Abstract:

Among the 25 fractions obtained from the alcohol extractive of the roots of Lantana camara L.(Verbenaceae) by silica gel column chromatography, three fractions demonstrated inhibitory HIV-1 reverse transcriptase activity. Furthermore, six pentacyclic triterpenes were isolated by reduced pressure column chromatography and identified as oleanonic acid(1), liquidambaric lactone(2), lantadene A(3), lantadene B(4), oleanolic acid(5), and 25-hydroxy-oleanolic acid(6) by spectral analysis. Compounds 2 and 6 were reported firstly in the plants of Verbenaceae family, and the structure of 6 was confirmed firstly by X-ray crystallography.

Key words: roots of Latana camara L., HIV RT, pentacyclic triterpenes, single crystal structure

中图分类号:

R248.2 Q946.91

何俊杰，郑炼付，霍天武，王婷婷，曾和平. 马缨丹根：化学成分及抑制HIV逆转录酶活性[J]. 天然产物研究与开发, 2011, 23(1): 25-29.

HE Jun-Jie, ZHENG Lian-Fu, HUO Tian-Wu, WANG Ting-Ting, ZENG He-Ping. Roots of Lantana camara: Chemical Constituents and HIV-1 Reverse Transcriptase Inhibitory Activity[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(1): 25-29.

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