内蒙古产柽柳和多枝柽柳α-葡萄糖苷酶抑制活性

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (1): 146-148.

内蒙古产柽柳和多枝柽柳α-葡萄糖苷酶抑制活性

常星^1,2，崔维恒¹，张俊柯¹，吴雨虹¹，康文艺^1*

¹河南大学天然药物研究所，开封，475004；²河南大学研究生院，开封，475001

收稿日期:2009-09-07 发布日期:2011-07-20
通讯作者: kangweny@hotmail.com
基金资助:
河南大学大学生创新性实验计划（09NB026），河南省教育厅青年骨干教师资助计划（教高[2008]755）

α-Glucosidase Inhibitory Activity of Tamarix chinensis Lour. and Tamarix ramosissima Ledeb. in Nei Meng-gu

CHANG Xing^1,2, CUI Wei-heng¹, ZHANG Jun-ke¹, WU Yu-hong¹, KANG Wen-yi^1*

¹ Institute of Natural Products, Henan University, Kaifeng 475004, China; ²Graduate School of Henan University, Kaifeng 475001, China

Received:2009-09-07 Published:2011-07-20

摘要/Abstract

摘要：

首次利用体外α-葡萄糖苷酶抑制模型以96微孔板法，对内蒙古产2种柽柳属植物不同溶剂提取物进行活性评价，并与阳性对照Acarbose比较，发现6种提取物均有较好的α-葡萄糖苷酶抑制作用，远远强于阳性对照Acarbose（IC₅₀ = 1103.01 μg•mL^-1）的抑制活性。结果显示，同一植物不同溶剂提取物相比较，两者石油醚提取物α-葡萄糖苷酶抑制活性不及乙酸乙酯和甲醇提取物；不同植物同一溶剂的提取物抑制活性也不同，6种提取物中，多枝柽柳的甲醇和柽柳的乙酸乙酯提取物抑制活性最高（IC₅₀ = 13.36和17.35 μg•mL^-1）。所有提取物对α-葡萄糖苷酶活性的抑制效果均很好，且多枝柽柳抑制活性整体上较柽柳好，具有良好的潜在开发价值。

关键词: 柽柳属, 柽柳, 多枝柽柳, α-葡萄糖苷酶, 抑制活性

Abstract:

The α-glucosidase inhibitory activities of different extracts from two species Tamarix in Nei Meng-gu were screened and compared with acarbose as positive control in vitro by the 96-microplate-based method for the first time. The results showed that six extracts from two species Tamarix showed good inhibitory activity, and they were all greatly higher than that of acarbose (IC₅₀ = 1103.01 μg•mL^-1) as positive control. Petroleum ether extract had lower inhibitory activity than that of ethyl acetate extract and methanolic extract in the same plant. Extracts from different plant of same polar solvent had different inhibitory activity. In six extracts, the methanolic extract of T. ramosissima and ethyl acetate extract of T. chinensis had the highest inhibitor activity of α-glucosidase (IC₅₀ = 13.36和17.35 μg•mL^-1). The all extracts of two species Tamarix in Nei Meng-gu had good inhibitory activity of α-glucosidase, and inhibitory activity of T. ramosissima was higher than that of T. chinensis. Two plants could be exploited the diabetes drugs as α-glucosidases inhibitors in future.

Key words: Tamarix, T. chinensis, T. ramosissima, α-glucosidase, inhibitory activity

常星, 崔维恒，张俊柯，吴雨虹，康文艺. 内蒙古产柽柳和多枝柽柳α-葡萄糖苷酶抑制活性[J]. 天然产物研究与开发, 2011, 23(1): 146-148.

CHANG Xing, CUI Wei-Heng, ZHANG Jun-Ke, WU Yu-Hong, KANG Wen-Yi. α-Glucosidase Inhibitory Activity of Tamarix chinensis Lour. and Tamarix ramosissima Ledeb. in Nei Meng-gu[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(1): 146-148.

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