内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性

doi:A

天然产物研究与开发 ›› 2012, Vol. 23 ›› Issue (2): 216-218.doi: A

内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性

常星^1,2，康文艺^2*

¹中国医学科学院北京协和医学院药用植物研究所，北京 100193；²河南大学中药研究所，开封 475004

收稿日期:2009-06-15 出版日期:2012-02-29 发布日期:2012-03-23
基金资助:
河南省教育厅基础研究计划（2008A360002）；河南省教育厅青年骨干教师资助计划（教高2008-755）

α-Glucosidase Inhibitory Activitives of S.xanthoxylon Bunge, N.tangutorum Bobr and N.sibirica Pall,grown in Neimenggu from Zygophyllaceae

CHANG Xing^1,2，KANG Wen-yi^2*

¹Institute of Medicinal plant development,Chinese Acdemy of Medical Sciences &Peking Union Medical College,Beijing 100193,China;²Institute of Chinese Materia Medica,Henan University,Kaifeng 475004,China

Received:2009-06-15 Online:2012-02-29 Published:2012-03-23

摘要/Abstract

摘要： 首次利用体外α-葡萄糖苷酶抑制模型对内蒙古产3种蒺藜科植物的9个提取物进行活性评价，并与阳性对照Acarbose比较，发现3种植物均有抑制α-葡萄糖苷酶活性。其中白刺石油醚提取物对α-葡萄糖苷酶的抑制活性（IC₅₀=81.80 mg/L）最高，其余依次为小果白刺乙酸乙酯提取物（IC₅₀=610.29 mg/L），霸王石油醚（IC₅₀=627.22 mg/L）和乙酸乙酯提取物（IC₅₀=838.40 mg/L），它们的抑制活性远大于阳性对照Acarbose（IC₅₀=1103.01 mg/L）。结果发现，不同植物不同溶剂提取物的α-葡萄糖苷酶抑制活性不同。同一植物不同溶剂提取物相比较，甲醇提取物的α-葡萄糖苷酶抑制活性不及乙酸乙酯和石油醚提取物。

关键词: 蒺藜科；霸王；白刺；小果白刺；&alpha, -葡萄糖苷酶；抑制活性

Abstract: The α-glucosidase inhibitory activities of nine extracts from three species of Zygophyllaceae in Neimenggu were evaluated in vitro by 96-microplate-based method for the first time.All these three species showed α-glucosidase inhibitory activities compared with the positive control “acarbose”.Among these nine extracts,petroleum ether extract of Nitraria tangutorum Bobr.had the highest inhibitory activity (IC₅₀=81.80 mg/L),followed by the ethyl acetate extract of N.sibirica Pall（IC₅₀=610.29 mg/L）,the petroleum ether extract (IC₅₀ =627.22 mg/L) and ethyl acetate extract (IC₅₀=838.40 mg/L) of Sarcozygium xanthoxylon Bunge,all of which are much higher than that of acarbose (IC₅₀=1103.01 μg/mL) .Different extracts of different plants showed different inhibitory activies,while the inhibitory activity of different extracts from the same plant varied a lot.The methanolic extract had lower inhibitory activity than that of ethyl acetate extract and petroleum ether extract.

Key words: Zygophyllaceae；S.xanthoxylon Bunge；N.tangutorum Bobr.；N.sibirica Pall.；&alpha, -glucosidase；inhibitory activity

中图分类号:

Q946.81 R285

常星，康文艺. 内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性[J]. 天然产物研究与开发, 2012, 23(2): 216-218.

CHANG Xing，KANG Wen-yi. α-Glucosidase Inhibitory Activitives of S.xanthoxylon Bunge, N.tangutorum Bobr and N.sibirica Pall,grown in Neimenggu from Zygophyllaceae[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(2): 216-218.

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内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性

α-Glucosidase Inhibitory Activitives of S.xanthoxylon Bunge, N.tangutorum Bobr and N.sibirica Pall,grown in Neimenggu from Zygophyllaceae

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