天然产物研究与开发 ›› 2012, Vol. 23 ›› Issue (6): 790-.doi: A

• 研究简报 • 上一篇    下一篇

苍术及其麸炒品挥发油化学成分及抑制α-葡萄糖苷酶比较研究

王金梅,康文艺*   

  1. 河南大学中药研究所,河南开封475004
  • 收稿日期:2010-02-03 出版日期:2012-07-04 发布日期:2012-07-06

Study on Volatile Oil and Inhibition of Alpha-glucoside of Atractylodes Chinensis and A. Chinensis Preparata

WANG Jin-mei, KANG Wen-yi*   

  1. Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China
  • Received:2010-02-03 Online:2012-07-04 Published:2012-07-06

摘要: 为了研究苍术麸炒前后挥发油的化学成分及降血糖活性的变化,我们采用水蒸气蒸馏法提取苍术生品和麸炒品的挥发油,用气相色谱-质谱技术分析,并采用体外α-葡萄糖苷酶抑制模型进行酶抑制活性研究。结果表明生苍术麸炒后挥发油含量显著降低,烯类、苯类、萘类及环己烯类化合物的显著减少,而[2R-(2α,4aα,8aβ)]-十氢-α,α,4a-三甲基-8-亚甲基-2-萘甲醇和联苯甲酯明显增加;α-葡萄糖苷酶活性降低,抑制强度依次为生苍术> 麸炒苍术>阿卡波糖(阳性对照)。表明苍术挥发油有较好的抑制α-葡萄糖苷酶活性作用。

关键词: 苍术;麸炒苍术;挥发油;抑制&alpha, -葡萄糖苷酶

Abstract: To study the chemical components and inhibition of alpha-glucosidase of volatile oil from Atractylodes chinensis and A. chinensis preparata, the volatile oil was extracted by steam distillation and analyzed by GC-MS technique, and α-glucosidase inhibitory activities were assayed in external. The content of volatile oil in A. chinensis decreased after stired with wheat bran, especially, alkenes, benzene, naphthalenes and cyclohexenes, and the content of [2R-(2α,4aα,8aβ)]-decahydro-α,α,4a-trimethyl-8-methylene-2-Naphthalenemethanol and [1,1'-Biphenyl]-4-carboxal dehyde increased. The α-glucosidase inhibitory activities: A. chinensis > A. chinensis preparata > Acarbose (positive control). The results shows that the volatile oil in A. chinensis has activity against α-glucosidase.

Key words: Atractylodes chinensis, A. chinensis preparata, α-glucosidase inhibitory activities

中图分类号: 

R284.1