9种中药提取物黄嘌呤氧化酶抑制活性研究

天然产物研究与开发 ›› 2014, Vol. 26 ›› Issue (4): 597-600.

9种中药提取物黄嘌呤氧化酶抑制活性研究

杨道茂1*，欧阳明安2

1 华侨大学化工学院生物工程系油脂与天然产物实验室，厦门 361021；2 福建农林大学生物农药和化学生物学教育部重点实验室，福州 350002

出版日期:2014-04-30 发布日期:2014-11-19

Xanthine Oxidase Inhibitory Activity of Extracts Obtained from 9 Chinese Herbal Medicines

YANG Dao-mao1*, OUYANG Ming-an2

1 Laboratory of Oil and Natural Product,Department of Biotechnology and Bioengineering,Huaqiao University,Xiamen 361021,China; 2 Key Laboratory of Biopesticide and chemistry Biology,Ministry of Education,Fujian Agriculture and Forestry University,Fuzhou 350002, China

Online:2014-04-30 Published:2014-11-19

摘要/Abstract

摘要： 本文考察9种中药植物（葛花、卷柏、卷柏根、猫须草、鹅不食草、高良姜、绞股蓝、鸡骨草、金银花）提取物对黄嘌呤氧化酶抑制活性。结果表明9种中药提取物在2 mg/mL时均具有较好抑制活性，抑制率从33%~79%不等。葛花、猫须草和金银花半抑制浓度分别是0.65、0.96、0.74 mg/mL，且猫须草、葛花抑制类型属于竞争性抑制为主的复合抑制。

关键词: 黄嘌呤氧化酶抑制活性, 中药材, IC₅₀, 复合抑制

Abstract: In this study,the xanthine oxidase inhibitory activities of extracts obtained from 9 Chinese herbal medicines (Flos puerariae, Herba selaginellae, root of Herba selaginellae, Orthosiphonari status, Herba centipedae, Alpinia officinarum Hance, Gynostemma pentaphyllum (Thunb.) Makino,Herba abri, Lonicera japonica) were investigated.The results showed that all extracts had significant inhibitory effects under the concentration of 2 mg/mL,and the inhibition rate ranged from 33% to 79%.The half-inhibitory concentrations (IC₅₀) of F.puerariae, O.status, L.japonica were determined to be 0.65,0.96,0.74 mg/mL,respectively.The inhibition type was of competitive-induced mixed inhibition.

Key words: xanthine oxidase inhibitory activity, Chinese herbal plants, IC₅₀, mixed inhibition

中图分类号:

R285.1

杨道茂1*，欧阳明安2. 9种中药提取物黄嘌呤氧化酶抑制活性研究[J]. 天然产物研究与开发, 2014, 26(4): 597-600.

YANG Dao-mao1*, OUYANG Ming-an2. Xanthine Oxidase Inhibitory Activity of Extracts Obtained from 9 Chinese Herbal Medicines[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(4): 597-600.

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