吴茱萸碱超微粉-F68固体分散体溶出研究

doi:10.16333/j.1001-6880.2015.09.021

天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (9): 1626-1629.doi: 10.16333/j.1001-6880.2015.09.021

吴茱萸碱超微粉-F68固体分散体溶出研究

杨红梅1，盛蓉2*，宋英2，曹蕾1，唐安玲1

1 成都中医药大学，成都610075；2 成都中医药大学附属医院，成都610072

出版日期:2015-09-25 发布日期:2015-09-28

Dissolution of Ultrafine EVO-F68 Solid Dispersion

YANG Hong-mei1, SHENG Rong2*, SONG Ying2, CAO Lei1, TANG An-ling1

1 College of Pharmacy,Chengdu University of TCM,Chengdu 610075,China; 2 Teaching Hospital of Chengdu University of Traditional Chinese Medicine (TCM), Chengdu 610072,China

Online:2015-09-25 Published:2015-09-28

摘要/Abstract

摘要： 本实验旨在研究固体分散技术对吴茱萸碱（Evodiamine，EVO）的溶解度和溶出度的影响。以泊洛沙姆188（F68）为载体，熔融法制备吴茱萸碱固体分散体，通过X射线粉末衍射法、红外图谱分析药物在固体分散体中的存在状态和HLPC法测定EVO固体分散体的溶出度，采用相似因子f₂分析不同处理方法对EVO固体分散体溶出度的影响。结果显示制备的分散体不影响EVO药物的含量和形态且大大提高EVO的溶出，该技术稳定可行且确定EVO与F68按1:4为较优配比值。

关键词: 吴茱萸碱, F68, 固体分散体, 溶出度

Abstract: The objective of this study was to investigate the effect of solid dispersion on dissolution and solubility of evodiamine.The solid dispersion was prepared by melting method and poloxamer188 (F68) acted as the carrier.The distribution condition were analyzed using X-ray diffraction and infrared spectrum.The dissolution of the solid dispersions was detected by HLPC.Similarity factor f₂ was used to determine the effect of dissolution on different treatment methods.According to the result of these tests,the dissolution of ultrafine EVO-F68 solid dispersion was evaluated.The results showed that evodiamine solid dispersions technology can significantly increase the dissolution of EVO,which cannot affect the content and structure of EVO and even greatly improved the dissolution.The optimal ratio of EVO and F68 was 1:4. Preferable solid dispersion was time-saving,highly efficient and reliable.

Key words: evodiamine, F68, solid dispersion, dissolution

中图分类号:

Q944.4

杨红梅1，盛蓉2*，宋英2，曹蕾1，唐安玲1. 吴茱萸碱超微粉-F68固体分散体溶出研究[J]. 天然产物研究与开发, 2015, 27(9): 1626-1629.

YANG Hong-mei1, SHENG Rong2*, SONG Ying2, CAO Lei1, TANG An-ling1. Dissolution of Ultrafine EVO-F68 Solid Dispersion[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(9): 1626-1629.

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吴茱萸碱超微粉-F68固体分散体溶出研究

Dissolution of Ultrafine EVO-F68 Solid Dispersion

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