蛋白性半胱氨酸蛋白酶抑制因子（CPIs）及在鱼类中的研究进展

doi:10.16333/j.1001-6880.2015.09.030

天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (9): 1679-1686.doi: 10.16333/j.1001-6880.2015.09.030

蛋白性半胱氨酸蛋白酶抑制因子（CPIs）及在鱼类中的研究进展

李树红*，蒋然然，马璐阳

四川农业大学食品学院，雅安 625014

出版日期:2015-09-25 发布日期:2015-09-28

Review on Proteinaceous Cysteine Proteinase Inhibitors and Their Research Progress in Fish

LI Shu-hong*, JIANG Ran-ran, MA Lu-yang

Food Science College,Sichuan Agricultural University,Yaan 625014,China

Online:2015-09-25 Published:2015-09-28

摘要/Abstract

摘要： 本文主要介绍了蛋白性半胱氨酸蛋白酶抑制因子（CPIs），并特别对第一类群（即Cystatins超家族）的结构特征、抑制机制及其多种活性、功能进行了概述；在此基础上，进一步对各种鱼类来源CPIs的纯化、鉴定现状及其在鱼类发育保护、免疫调节、肿瘤抑制及抑菌等方面的潜在活性、功能做以系统的综述，并展望了鱼类CPIs的可能应用前景。

关键词: 半胱氨酸蛋白酶抑制因子, 鱼类CPIs, 纯化鉴定, 活性及功能, 应用前景

Abstract: This paper mainly overviewed cysteine proteinase inhibitors (CPIs),summarized the structural feature,inhibition mechanism as well as various activities and functions of the first group (Cystatins superfamily) of CPIs.In addition,a systematic review about the purification and characterization of CPIs from fish were presented.The potential activities and functions of fish CPIs in respect of development protection,immunoregulation,tumor inhibition and antibacterial action were summarized.Finally,the possible applications of fish CPIs were expected.

Key words: cysteine protease inhibitors, CPIs from fish, purification and characterization, activity and function, application prospect

中图分类号:

TS254

李树红*，蒋然然，马璐阳. 蛋白性半胱氨酸蛋白酶抑制因子（CPIs）及在鱼类中的研究进展[J]. 天然产物研究与开发, 2015, 27(9): 1679-1686.

LI Shu-hong*, JIANG Ran-ran, MA Lu-yang. Review on Proteinaceous Cysteine Proteinase Inhibitors and Their Research Progress in Fish[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(9): 1679-1686.

蛋白性半胱氨酸蛋白酶抑制因子（CPIs）及在鱼类中的研究进展

Review on Proteinaceous Cysteine Proteinase Inhibitors and Their Research Progress in Fish

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