天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (Suppl): 1-5.doi: 10.16333/j.1001-6880.2015.S.001

• 研究论文 •    下一篇

地稔中酚酸类化学成分研究

程淼,霍揽明,李先盛,刘百联,周光雄*   

  1. 暨南大学药学院中药及天然药物研究所,广州 510632
  • 出版日期:2015-12-01 发布日期:2016-01-12

Chemical Constituents of Phenolic Acids in Melastoma dodecandrum

CHENG Miao, HUO Lan-ming, LI Xian-sheng, LIU Bai-lian, ZHOU Guang-xiong*   

  1. Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University,Guangzhou 510632,China
  • Online:2015-12-01 Published:2016-01-12

摘要: 采用硅胶、Sephadex LH-20、ODS 柱层析等色谱技术,从地稔95%乙醇提取物的乙酸乙酯萃取部位分离得到16个化合物。通过波谱分析并与文献数据对照方法,将其分别鉴定为反式阿魏酰二十烷醇酯(1)、邻羟基苯甲酸(2)、香草酸(3)、对香豆酸(4)、没食子酸甲酯(5)、没食子酸乙酯(6)、原儿茶酸(7)、没食子酸(8)、3-甲氧基鞣花酸(9)、3,3′-O-二甲基鞣花酸-4-O-α-L-鼠李糖苷(10)、4-O-(6″-O-对-香豆酰基-β-D-吡喃葡萄糖)-对-香豆酸(11)、2-O-(E)-咖啡酰基-1-O-对-(E)-香豆酰基-β-D-吡喃葡萄糖(12)、1,5-二咖啡酰奎尼酸(13)、对羟基苯乙酮(14)、aviculin(15)、苍耳烯吡喃(16)。其中除化合物8外,其他15个化合物均为首次从地稔中分离得到。

关键词: 地稔, 化学成分, 酚酸类

Abstract: Sixteen compounds were isolated and purified from EtOAc fraction derived from 95% ethanol extract of Melastoma dodecandrum Lour by silica gel,Sephadex LH-20 and ODS column chromatography.On the basis of their physicochemical properties and spectroscopic data,these compounds were identified as eicosyl-(E)-ferulate (1), oxybenzoic acid (2), vanillic acid (3), p-coumaric acid (4),methyl gallate (5),ethyl gallate (6),protocatechuic acid (7),gallic acid (8),3-O-methylellagic acid (9),3,3′-O-dimethyl ellagic acid 4-O-α-L-rhamnopyranoside (10),4-O-(6″-O-p-coumaroyl-β-D-glucopyranosyl)-p-coumaric acid (11),2-O-(E)-caffeoyl-1-O-p-(E)coumaroyl-β-D-glucopyrannose (12),1,5-di-O-caffeoylquinicacid (13), p-hydroxyacetophenone (14),aviculin (15),xanthienopyran (16).All of these compounds except compound 8 were obtained from Melastoma dodecandrum Lour for the first time.

Key words: Melastoma dodecandrum L, chemical constituents, phenolic acids

中图分类号: 

R284.2