天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (2): 222-227.doi: 10.16333/j.1001-6880.2016.2.009

• 研究简报 • 上一篇    下一篇

木竹子枝叶的化学成分及细胞毒和抗炎活性研究

范翊民1,2,田东松1,2,顾伟2,黄烈军2, 苑春茂2*,郝小江2*   

  1. 1 贵州大学药学院,贵阳 550025;2 贵州省中国科学院天然产物化学重点实验室,贵阳 550002
  • 出版日期:2016-02-29 发布日期:2016-03-07

Chemical Constituents from the Leaves and Twigs of Garcinia multiflora and Their Cytotoxic as well as Anti-inflammatory Activity

FAN Yi-min1,2,TIAN Dong-song1,2,GU Wei2,HUANG Lie-jun2,YUAN Chun-mao2*,HAO Xiao-jiang2*   

  1. 1 College of Pharmacy in Guizhou University,Guiyang 550025 China; 2 The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences,Guiyang 550002,China
  • Online:2016-02-29 Published:2016-03-07

摘要: 采用硅胶柱色谱和HPLC等分离方法,对木竹子Garcinia multiflora枝叶的化学成分进行分离纯化,依据理化性质及波谱数据分析进行结构鉴定,从中分离鉴定了10个单体化合物,分别为:sampsonione L (1)、hyperibone G(2)、garcicowin C(3)、isogarcinol(4)、garcinialone(5)、clovane-2,9-diol(6)、 caryolane-1,9-β-diol(7)、异茴芹灵(8),1,2,4-苯三酚(9)和2-羟基-4,6-二甲氧基苯乙酮(10)。化合物1~3和6~10为首次从该植物中分离得到,其中1~2和5~9为首次从该属植物中分离得到。对分离得到的多环多异戊烯基间苯三酚类化合物(1~5)进行了细胞毒和抗炎活性筛选,结果显示化合物3~5具有较好的细胞毒和抗炎活性。

关键词: 木竹子, 化学成分, 多环多异戊烯基间苯三酚, 细胞毒和抗炎活性

Abstract: Ten compounds were isolated and purified by silica gel column chromatography and HPLC from the leaves and twigs of Garcinia multiflora. Their structures were identified as sampsonione L (1),hyperibone G (2),garcicowin C (3),isogarcinol (4),garcinialone (5),clovane-2,9-diol (6),caryolane-1,9-β-diol (7),isopimpinellin (8),1,2,4-trihydroxybenzene (9) and 2-hydroxy-4,6-dimethoxyacetophenone (10) by physicochemical properties and spectral data.Compounds 1-4 and 6-10 were isolated from the titled plant for the first time,and compounds 1-2 and 6-9 were firstly reported from the genus Garcinia. Five polycyclic polyprenylated acylphloroglucinols (1-5) were evaluated for the cytotoxic and anti-inflammatory activities and compounds 3-5 showed moderate cytotoxic and anti-inflammatory activities.

Key words: Garcinia multiflora, hemical constituents, polycyclic polyprenylated acylphloroglucinols, cytotoxic and anti-inflammatory activities

中图分类号: 

R284.1