NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (1): 80-83.doi: 10.16333/j.1001-6880.2015.01.017

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Preparation of Ethyl-3-(3,4-dihydroxyphenyl)-2-Hydroxypropanoate from Aqueous Extract of Salvia mitiorrhiza

QIAN San-li1, LI Bing-yu1, WU Jun-yi2, ZHANG Zhen-zhong1, YANG Chun-jie1, ZOU Yun-zeng1*   

  1. 1 Fudan University Affiliated Zhongshan Hospital,Shanghai 200032,China;2 Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China
  • Online:2015-01-31 Published:2015-02-12

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Abstract: A method to prepare ethyl-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate was established.The aqueous extract of Salvia miltiorrhiza was dissolved in ethanol and concentrated sulfuric acid was added as the catalyst,and ethyl-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate was synthesized under the reflux of ethanol.The DPPH radical elimination tests showed that ethyl-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate had a higher radical eliminate ability compared to Danshensu.This study provided a simple,low cost but effective method to prepare Danshensu derivatives.

Key words: Danshensu, ethyl-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate, derivative, DPPH

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