Abstract: The improper activation of complement system may lead to a variety of diseases,such as rheumatoid arthritis and Alzheimer’s disease.Anti-complementary agents prepared by chemical synthesis have the limitations such as high cost,low selectivity and unwanted side effects.Therefore,natural products as anti-complementary agents have received worldwide attention.Up to now,a number of anti-complementary natural products have been isolated from animals,plants and microorganisms,which include polysaccharides,flavones,terpenes,steroids,saponins and alkaloids.In this review,the anti-complementary constituents newly discovered during the recent years were summarized.The prospect on the development of anti-complementary agents derived from natural products,especially from microorganisms,were also discussed.Due to the ease of cultivation and genetic manipulation,as well as convenience in quality control,anti-complementary compounds from microorganisms deserve more attention.

Key words: anti-complementary activity, natural product, anti-complementary agent, polysaccharide, saponin, terpene