Abstract: The objective of this study was to optimize the decoction process of Stigma maydis dispensing granule,and hence to increase the concentration of its effective composition.The effect of liquid-solid ratio,soaking time,times of boiling and boiling duration in the decoction process was investigated using quantity of extract,concentrations of polysaccharides and total flavonoids extracted out as indexes.Through standard decoction test,orthogonal test and validation test,the optimal decoction conditions were determined to be:25 times of water,soaking 60 min,decoction for 3 times,each time 30 min.The optimized decoction process was proved to be stable and reliable.

Key words: Stigma maydis, extraction process, polysaccharide, total flavonoid