Abstract: Five compounds were synthesized by coupling paeonol or its analogues with ibuprofen using DCC method or acyl chloride method. All the synthesized compounds were new,except for compound A. The structures of all synthesized compounds were characterized by IR, ¹H NMR and mass spectrometry. Anti-inflammatory activities of the compounds were evaluated in xylene-induced mice ear swelling model. The results showed that the synthesized compounds exhibited potent anti-inflammatory activities (P<0.01).

Key words: paeonol, structural analogues, ibuprofen, anti-inflammatory activity