Abstract: In this study,xylitol mother liquid was purified using simulated moving bed (SMB) chromatography.Based on the research results of single column chromatographic system,the technological parameters of SMB and sequential simulated moving bed (SSMB) for the purification of xylitol mother liquid were optimized.As a result,the optimized parameters were:60% as feed concentration,546.00 g/h as feed rate,819.00 g/h as amount of water consumption and 382.2 mL as the volume of circulation.Under these conditions,the concentration of purified xylitol was 41.2% with the purity of 94.8% and the recovery was 90.6%,which was 31.12% higher than xylitol mother liquid.These findings may be useful for large scale purification of xylitol mother liquid production.

Key words: xylitol mother liquid, simulated moving chromatography, sequential simulated moving bed chromatography, preparative chromatography