NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (12): 2027-2030. doi: 10.16333/j.1001-6880.2015.12.005

• Article • Previous Articles     Next Articles

Synthesis and in vitro Anti-Tumor Effects of Hydroxytanshinone IIA

ZHANG Li-juan, XU Wen-qing*, JIANG Cheng-feng, YANG Fu-jun, SHEN Xiu   

  1. Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China
  • Online:2015-12-29 Published:2016-01-06

PDF (PC)

378

Abstract: Hydroxytanshinone IIA was synthesized with tanshinone IIA as lead compound.MTT assay was adopted to evaluate its inhibition effect against Hela,HepG-2 and SGC-7901 cells.Results indicated that hydroxytanshinone IIA inhibited cell proliferation in a dose-dependent manner.The half inhibitory concentrations (IC50) of hydroxytanshinone IIA against SGC-7901,HeLa and HepG-2 cells were 4.18 μM,6.08 μM and 10.20 μM,respectively.But the IC50 of tanshinone IIA against SGC-7901,HeLa and HepG-2 cells were 17.15 μM,27.28 μM and 46.34 μM,respectively.The inhibition effect of hydroxytanshinone IIA to SGC-7901 cells was powerful.Compared with tanshinone IIA,hydroxytanshinone IIA significantly increased inhibition effect (P<0.05).

Key words: tanshinone IIA, hydroxytanshinone IIA, Hela cells, HepG-2 cells, SGC-7901 cells

CLC Number: