Abstract: To compare the ingredient and pharmacological activity of ethanol extracts of wild and cultivated Swertia mussotii Franch. The method of HPLC and infrared spectroscopy was used to compare the ingredient of extracts of wild and cultivated S. mussotii Franch;liver injury model induced by CCl₄ in mice,acetic acidinduced writhing experiment and normal mouse were used to compare the hepatoprotective function,abirritation and peristaltic inhibition of the extracts. The total content of swertiamarin,gentiopicrin and mangiferin of wild and cultivated S. mussotii Franch were 3.949% and 4.539% respectively;Infrared spectroscopy of ethanol extracts had no obvious difference,while two-dimensional correlation spectroscopy (2D-COS) of them had evident difference. The pharmacological experiments results proved their hepatoprotective function,abirritation and peristaltic inhibition,while the enhancement pharmacological activity of cultivated sample with the increasing of dosage was more obvious when it compared with that of wild sample.

Key words: Swertia mussotii Franch, wild, cultivated, infrared spectroscopy, pharmacological activity