NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (4): 494-497. doi: 10.16333/j.1001-6880.2016.4.005

• Article • Previous Articles     Next Articles

A New Natural Product from Streptomyces sp.neauD50

ZHANG Hui,QI Huan,ZHANG Ling-jian,XIANG Wen-sheng,WANG Ji-dong*   

  1. Zhejiang Hisun Pharmaceutical Co.,Ltd.,Zhejiang Taizhou 318000,China
  • Online:2016-04-30 Published:2016-05-13

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Abstract: The chemical constituents of borrelidin-producing strain Streptomyces sp.neau-D50 was reinvestigated and a new natural product (N-acetylborrelidin B) was obtained. N-Acetylborrelidin B exhibited cytotoxic activity against human breast adenocarcinoma cell line MCF-7 and murine melanoma cell line B-16 with IC50 values of 19.9 μM and 36.3 μM,respectively.

Key words: borrelidin analogue, Streptomyces;secondary metabolite;cytotoxic activity

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