Abstract: In this study,the invitro antiviral activity of Ardisia japonica (Thunb.)Blume were evaluated by cytopathic effect (CPE) method and CCK-8 kit with 4different strains of viruses,including RSV,HSV-1,COX-B5 and EV71.The therapeutic indexes were calculated by Reed-Muench method.Antivirus stability experiments of A.jonica were carried out at the same time.The results showed thecytopathic effect caused byRSV,HSV-1 and COX-B5were significantly inhibited,the TI of 70% ethanol parts and ribavirin were 16.709 and 17.482,respectively.It showed that 70% ethanol parts was as effective as the ribavirin.All the results indicated that A.japonica had antiviral activity against RSV,HSV-1 and COX-B5.

Key words: Ardisia japonica (Thunb.)Blume, antiviral, RSV, HSV-1, COX-B5