Two Anthrabenzoxocinone Metabolites from Streptomyces sp.HS-NF-496

doi:10.16333/j.1001-6880.2017.10.009

Abstract

Abstract: Two anthrabenzoxocinone metabolites,(-)-(6R,16R) 10-Cl-ABX (1) and (-)-(6R, 16R)-ABX (2),were isolated from the fermentation broth of Streptomyces sp.HS-NF-496.Their structures were determined on the basis of spectroscopic analysis,including 1D and 2D NMR techniques,CD as well as ESI-MS and comparison with data from the literatures.Bioassay results showed that 1 and 2 exhibited weak cytotoxic activity against three tumor cell lines A549,HCT-116 and SF-268 and moderate antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Methicillin-resistant S.aureus. The absolute configuration of 1 was reported for the first time.

Key words: Streptomyces sp, anthrabenzoxocinones, cytotoxicity, antibacterial activity

CLC Number:

R284.1

DU Min-na, JIANG Nan, ZHANG Ling-jian, ZHANG Hang-feng, QI Huan, ZHANG Hui*, WANG Ji-dong. Two Anthrabenzoxocinone Metabolites from Streptomyces sp.HS-NF-496[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(10): 1683-1687.

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Two Anthrabenzoxocinone Metabolites from Streptomyces sp.HS-NF-496

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