Abstract: In order to investigate bioactive metabolites from endophytic fungi,a fungal strain GZWMJZ-39 was isolated and identified as Penicillium cavernicola from the bulb of Lycoris aurea Herb in Guiyang Guizhou,China.The fermentation extract was purified by column chromatography over silica gel,Sephadex LH-20 and semi-preparative HPLC.The structures of isolated compounds were identified by NMR and MS.As a result,six compounds,peniginseng B (1),peniginseng A (2),4-(3,4-dihydroxybenzamido) butanoic acid (3),methyl 4-(3,4-dihydroxybenzamido) butanoate (4),peniamidone B (5) and chaetoglobosin G (6),were obtained.Compounds 1-5 exhibited good radical scavenging activities against DPPH with IC50 values ranged from 3.9 to 27.4 μM.Compound 1-6,at a concentration of 50 μg/mL,showed weak inhibitory activity against AChE with inhibition rates from 25.2% to 32.6%,respectively.

Key words: Lycoris aurea Herb, endophytic fungi, secondary metabolites, antioxidant, AChE