Abstract: To elucidate the differences of material base of volatile oils from the leaves,aerial parts and whole part of Pogostemonis herba and its correlation with anti-Candida albicans activity.The fingerprints of volatile oils were established by GC-MS.The common peaks of the three oils were relatively recognized and cluster analyzed by SPSS software to compare the fingerprint similarity and analyze of material differences.The anti-C.albicans activity was detected by double dilution method and the correlation with fingerprint was identified by grey relational analysis.The cluster analysis of the other two oils was found to be divided into the same categories and the similarities were perfectly correlated,except for the oil of leaves.Comparing with the aerial part,the whole plants had almost no change in the types and contents of the components except the drastically enhancing of patchoulenone.The oil of leaves contained no patchoulenone.The efficacy order of anti-C.albicans was as follows:the oil of whole part > the oil of aerial parts > the oil of leaves,and patchoulenone had the highest correlation with anti-C.albicans activity.In conclusion,the use of the whole plant instead of the aerial parts of P.cablin did not change the original components of the volatile oil,but increased the patchoulenone content.Furthermore,it also improved the effect of anti-C.albicans effect.

Key words: patchouli oil, different medicinal parts, GC-MS, patchoulenone, anti-Candidaalbicans