Abstract: In this study,the effects of sepia ink melanin (SIM) on glucose-lipid matabolism in diabetics mice induced by streptozotocin were investigated.Mice were randomly divided into 4 groups [normal group,model group,melanin (120,480 mg/kg) groups] with 10 mice in each group.Animals were gavaged with SIM or equal volume saline.After 4 weeks,a series of index were measured including glycated hemoglobin (HbA1c),glycosylated serum protein (GSP), fasting blood glucose,food intake,water intake,oral glucose tolerance test,serum insulin and insulin resistance index.The results showed that SIM significantly alleviated the level of glucose-lipid metabolism,and promoted the secretion of insulin in diabetic mice.In conclusion,sepia melanin ink (SIM) can ameliorate the symptom of diabetic mice through controlling blood sugar concentration,promoting the secretion of insulin and regulating glucose-lipid metabolism disorder.

Key words: melanin, diabetes, insulin resistance index, HbA1c, GSP