Abstract: The systematic review was performed to investigate the protective effects of proanthocyanidins on oxidative damage,which provides reference for revealing the mechanism of anti-oxidative damage by activating the Nrf2 signaling pathway.Literature was searched by independently searching databases,including the China National Knowledge Infrastucture,VIP,Wanfang data,CBM,Cochrane,PubMed,Springer,Web of Science to search for the data of intervention on experimental animals of proanthocyanidins.And a meta-analysis was to retrieve experimental data on PC and oxidative damage published both in China and worldwide in the past few years.The difference between groups was described by standard mean difference (SMD).Levels of SOD ［SMD=2.11,95% CI(1.45,2.78)］,GSH-Px ［SMD=2.88,95%CI (1.94,3.82)］,GSH ［SMD=4.45,95%CI (3.09,5.81)］,Nrf2 ［SMD=3.75,95%CI (2.35,5.15)］,NQO1 ［SMD=4.92,95%CI (0.65,9.19)］,HO-1 ［SMD=5.13,95%CI (2.01,8.25)］,GST ［SMD=4.77,95%CI (231,722)］ in the PC intervention group was higher than that of the oxidative injured model group (P<0.05)Levels of MDA ［SMD=-300,95%CI (-359,-241)］ in the PC intervention group was lower than that of the oxidative injured model group (P<0.05)While Nrf2 ［SMD=279,95%CI (0.64,4.94)］,HO-1 ［SMD=2.03,95%CI (0.17,389)］,GST ［SMD=2.23,95%CI (0.42,4.03)］ in the PC group was higher than control group (P<0.05)Subgroup analysis demonstrated that intervention time (≥35d or 24h) of PC was found to promote the production of Nrf2 (P=0.02);high intervention dose (>200mg/kg or 1mg/L) of PC increase the expression of Nrf2 (P=0.04)PC can protect against oxidative damage by activating the Nrf2 signaling pathway.High-dose and long-time intervention of PC can play a better role in antioxidative damage.

Key words: proanthocyanidins, NF-E2-related factor 2, oxidative stress, review, meta-analysis