Abstract: This study was to explore the effect and mechanism of capsaicin on gastric ischemia-reperfusion injury in rats.Specific methods were as follows:40 SD rats were randomly divided into 4 groups with 10 rats in each group，group A(control group),group B(operation group),group C(CAP group) and group D(CAP+operation group).Rats in group A and group B were treated with intragastric administration of normal saline 10 ml/kg/d,group C and group D with intragastric administration of CAP1mg/kg/d.After 4 weeks,the rats in group B and group D were killed 24 hours later after the establishment of GI-R model.Last,astric juice was collected to determine the total acidity of gastric acid,counted the gastric mucosal injury index,observed the gastric mucosa pathological injury,and detected the expression of TRPV1、CGRP、MDA、SOD.Results show that:the gastric mucosa of group A and C had no damage.Compared with group B,the gastric mucosa injury were significantly reduced（P＜0.05）,total acidity decreased significantly（P＜0.05）,MDA decreased significantly（P＜0.05）,SOD increased significantly（P＜0.05）and the expression of TRPV1、CGRP increased significantly（P＜0.05）in group D.Experimental results show that:it could prevent that GI-R induced acute gastric mucosal injury in rats by pretreated with CAP 1 mg/kg/d for 4weeks.The mechanism may be related to the up regulation of TRPV1 and CGRP expression in the stomach and the reduction of oxygen free radical damage by CAP.

Key words: CAP, GI-R , Gastric mucosal injury, TRPV1, CGRP