Abstract: Marine sponges of the genus Haliclona are widely distributed in marine ecosystems.A variety of chemical constituents with novel structures such as alkaloids,peptides,terpenoids,steroids,unsaturated aliphatic hydrocarbons,have been isolated from marine sponge Haliclona.Among them,the most common secondary metabolites of marine sponge Haliclona are alkaloids.In addition,many of secondary metabolites possess a variety of biological activities,such as cytotoxic,antimicrobial,antifouling,antitumor.This paper reviewed the chemical constituents and bioactivities from the sponges of genus Haliclona in recent 10 years,which is intended to provide guidance for the further research of chemical constituents and their bioactivities from the marine sponge Haliclona .

Key words: Haliclona sp., chemical constituents, bioactivity