Abstract: The structure and bioactivity diversities of Talaromyces pinophilus GMF19,an endophytic fungus derived from the rhizome of Suaeda glauce, have been researched.Eleven secondary metabolites were purified from its culture extract by the combination of silica gel,Sephadex LH-20,and RP-C₁₈ column chromatography,as well as the preparative high performance liquid chromatography.The structures were elucidated by the analyses of their spectroscopic data to be trichodermamides A (1),ergosterol (2),adenosine (3),kojic acid (4),5-hydroxy-4-oxo-4H-pyran-2-ethyl formate (5),kojic acid monomethyl ether (6),5-n-heneicosylresorcinol (7),caffeic acid methyl ester (8),(E)-caffeamide (9),2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzylalcohol (10) and Nb-acetyltryptamine (11).Besides of compound 2,other ten compounds were firstly reported to be isolated from the genus of Talaromyces.Compounds 2,3,5,and 7 showed antifungal activities against plant pathogenic fungi,while 1 and 4-6 exhibited brine shrimp lethalities,especially 4 with the LD₅₀ value of 7.4 μg/mL.

Key words: Suaeda glauce, endophytic fungus, secondary metabolites, antifungal activity, brine shrimp lethality