Abstract: In order to further optimize the energy saving and consumption reduction process for the preparation of total salvianolic acids,a ceramic membrane technology was developed and used to refine the yields of total salvianolic acids and salvianolic acid B.The hypoglycemic activity of salvianolic acid B was also evaluated using HepG2 cell model.The yield of total salvianolic acid was extracted by methods of water extraction and alcohol precipitation method,30% alcohol extraction and ceramic membrane ultrafiltration.Moreover,different apertures of ceramic membrane were used to evaluate efficiency of ultrafiltration,and HepG2 cell model was used to evaluate hypoglycemic activity.The results showed that ceramic membrane technology could significantly improve the yield of total salvianolic acid and salvianolic acid B,and the efficiency was significantly better than the other two methods.The insulin resistance model was successfully established to evaluate hypoglycemic activity of salvianolic acid B,which exhibit obvious hypoglycemic activity.Using ceramic membrane technology can significantly improve the yield of total salvianolic acid and the content of salvianolic acid B,and the process was simple and the sample quantity was well,it is vital that providing an energy saving technology for the extraction and preparation of total salvianolic acid,and could be candidates for anti-diabetic agents.

Key words: ceramic membrane, total salvianolic acid, salvianolic acid B, hypoglycemic activity