Abstract: Platelet activation and aggregation play an important role in the initiation and progression of thrombosis.Consequently,the anti-platelet therapy can be beneficial for the patients of coronary and cerebrovascular diseases.The anti-platelet drugs can effectively relieve the formation of thrombus,but there are still several problems,such as drug resistance,low response and complications.Many studies have shown that many bioactive peptides have significant anti-platelet activities which are from wide range of sources,safe and effective,with few side effects.This article firstly introduce the mechanism of platelet activation,then reviews the sources of anti-platelet peptides,peptide sequence,the effect of platelet aggregation that published in recent years,and probes into the mechanism of anti-platelet peptide,in order to provide reference for antiplatelet peptide as dietary supplement for functional food.

Key words: anti-thrombotic, anti-platelet, bioactive peptide, platelet aggregation