Abstract: In the present study,the inhibitory effect of Cynomorium procyanidins on the formation of advanced glycation end products (AGEs) was explored in simulated systems consisting of glucose/glycine. Cynomorium procyanidins as antioxidant,was incubated in the simulated systems at different concentrations and temperature levels with or without various metal ions,which was to observe its inhibitory effect.The results showed that the inhibitory effect on AGEs was reach to 85.73%±1.57% at the concentration of 1 mg/mL for 75min at 80  ℃,and 74.01%±1.45% for 30 min at 100  ℃.When metal ions (Al³⁺,Cu²⁺,Fe²⁺,Mg²⁺,Ca²⁺,Zn²⁺) were added to the simulated systems,the inhibition effects of the formation of AGEs was restraining and promoting.The addition of 0.1 and 1.0 mg/L Al³⁺ promoted the formation of AGEs at 80  ℃,whereas the addition of 0.1 ,1.0,and 10.0 mg/L Al³⁺ suppressed the AGEs formation at 100  ℃.After 1 mg/mL procyanidins was added,the inhibition ratio of the solution containing Al³⁺ with the concentration of 10.0 mg/L was the highest inhibition ratio at 80  ℃.The addition of Cu²⁺,Fe²⁺,Mg²⁺ with the concentration of 1.0,promoted the formation of AGEs in the glucose/glycine model system.However,after procyanidins were added,all concentrations of metal ions inhibited the formation of AGEs.The results can provide reference for the development of natural AGEs inhibitors and their application in food industry.

Key words: Cynomorium procyanidins, glucose/glycine model system, advanced glycation end products