To compare the content of flavonoids and the antioxidant activity difference of Zanthoxylum armatum DC. from different places of production,the correlation between flavonoids and antioxidant activity is explored.Taking Z. armatum from 21 producing areas as the materials,this paper establishes a method to simultaneously determine the contents of four types of flavonoids (inculding rutinum,hyperoside,isoquercitrin,quercitrin) with HPLC,test the content of total flavonoids by adopting spectrophotometry,evaluate its antioxidant activity through DPPH and ABTS free radical scavenging tests,and analyzes and explores the correlation between flavonoids and antioxidant activity combined with product-moment coefficient of correlation.The established method is simple and accurate which can be used in testing the contents of four types of flavonoids in Z. armatum;there are obvious differences in the content of flavonoids and the antioxidant activity of Z. armatum from different places;according to the correlation analysis results,it can be seen that the total flavonoids and rutinum are significantly negative to the EC₅₀ of both DPPH and ABTS clearance.Therefore,total flavonoids and rutinum can be used as indicators to evaluate the antioxidant capability of Z. armatum.This study provides an experimental basis for the antioxidant activity research of Z. armatum and a reference for the development of its health derivatives.