This study aims to explore the potential molecular mechanism of anti-hepatitis of Halenia elliptica D.Don by using UPLC-Q-TOF-MS/MS technology,network pharmacology and molecular docking methods.At first,the main chemical components were analyzed by UPLC-Q-TOF-MS/MS,and the targets were predicted by Swiss Target Prediction database.The key core targets were obtained by intersection of the results and the hepatitis related targets retrieved from DisGeNET and GeneCards databases.Secondly,protein interaction network was constructed by String database,and the results were imported into Cytoscape 3.6.0 software to construct protein interaction network and component target pathway network.Then GO function enrichment analysis and KEGG pathway enrichment analysis of target genes were carried out through David database.Finally,the potential active components predicted in the network were verified by molecular docking with the core target by using Autodock Vina and other software.The results showed 39 key active components and 33 potential targets.It plays an anti-hepatitis role mainly through the positive regulation of leukocyte migration,positive regulation of nitric oxide biosynthetic process,platelet activation,positive regulation of ERK1 and ERK2 cascade,regulation of phosphatidylinositol 3-kinase signaling and other biological processes,as well as TNF,PI3K,Toll-like receptor,FoxO,HIF-1,VEGF,Fc epsilon RI and other key signaling pathways.