To explore the clinical efficacy and mechanism of Danggui Shaoyao Powder in coronavirus disease 2019 (COVID-19),we collected and analyzed the clinical data containing basic signs,main symptoms,laboratory indicators,nucleic acid negative conversion,and CT imaging before and after Danggui Shaoyao Powder combined with conventional treatment of 100 COVID-19 patients admitted to Wuhan Union Hospital from January 20 to March 20,2020.The results showed that the clinical symptoms and laboratory indicators of these patients were significantly better than before.At the same time,we analyzed the potential targets of Danggui Shaoyao Powder in the treatment of COVID-19 through network pharmacology.Then we found 18 targets,180 items of GO function enrichment,and 109 items of KEGG pathway enrichment.The results suggested that Danggui Shaoyao Powder exerted its therapeutic effects in COVID-19 by modulating multiple targets and pathways,including anti-virus,anti-inflammation,and anti-oxidation.