To explore the mechanism of flavonoids of Isodonis Lophanthoidis Herba on alcoholic liver disease (ALD)based on network pharmacology.Ingredients were collected by literature,PubChem and TCMSP databases,and PharmMapper platform was used to predict targets of components,after that UniProt database was used to standardize targets names.Then the disease targets of ALD was obtained by GeneCards,and the intersection targets were obtained by Venny2.1.0.The protein interactions network was constructed by the STRING,then GO and KEGG pathway for intersection targets were analyzed through DAVID.The interactions network of flavonoids of Isodonis Lophanthoidis Herba-target-pathway was constructed by Cytoscape3.7.0,eventually molecular docking was used to verify core targets.In this paper,12 flavonoids from Isodonis Lophanthoidis Herba were collected,which involved 172 ALD-related targets and 24 core targets were screened.GO enrichment showed 52 biological processes,24 cellular components and 16 molecular functions,which mainly involved transcriptional regulation,apoptosis regulation,vascular endothelial growth factor,NF-κB regulation,lipid homeostasis,DNA damage and apoptosis and other biological processes.KEGG enriched 27 pathways,mainly involving key pathways such as PI3K/Akt signal,FoxO signal,p53 signal and so on.Molecular docking revealed that the core targets of HSP90AA1,VEGFA and CCND1 had good binding effect with active components.In summary,this paper indicates that flavonoids ofIsodonis Lophanthoidis Herba act on multiple targets,participate in the regulation of multiple pathways to exert the mechanism of treating ALD,which provides a basis for further verifying the related targets and pathways of flavonoids of Isodonis Lophanthoidis Herba in the treatment of ALD.