To establish the detection model of sex-enhancing drugs illegally added by the thin layer chromatography (TLC) and near-infrared spectroscopy (NIRS) combined technology,for the rapid qualitative and quantitative analysis of drugs illegally added in health care products.With the content of chemical drugs in health care products determined by HPLC method as a reference value.TLC was used in the study.Trichloromethane-methyl alcohol-ammonium hydroxide (10∶1∶0.1) was used as developing solvent and the plate was detected under ultraviolet lamp.The NIR spectrum of chemical component spots on TLC were collected by NIRS.The rapid qualitative and quantitative model of chemical drugs was established by using the partial least squares regression analysis (PLS) combined with cross validation method.And validated for model.Established the HPLC analysis method with better separation degree and wide linear range.Established the TLC-NIRS analysis models of sildenafil and noracetildenafil with wide linear range,and the better stable and predicted results.The correlation coefficient (R²),the root mean square error of calibration validation (RMSECV) and the root mean square error of prediction (RMSEP) were 0.984,0.085 and 0.081;0.982,0.098 and 0.087,respectively.Using the TLC-NIRS model,9 batches of in 10 batches of sex-enhancing products were detected to be added sildenafil and an unqualified rate of 90%,the average relative 〖JP3〗deviation of the content of sildenafil and noracetildenafil of predicted were 1.86%,1.96%,respectively.The results showed that the TLC-NIRS analysis models can be used for above chemical components rapid determination in sex-enhancing products.The method with specific and simple.Which provided the ideas for rapid determination of added illegally drugs in health care products.